4DA5
Choline Kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology
Summary for 4DA5
| Entry DOI | 10.2210/pdb4da5/pdb |
| Descriptor | Choline kinase alpha, SULFATE ION, (3R)-1-azabicyclo[2.2.2]oct-3-yl[bis(5-chlorothiophen-2-yl)]methanol, ... (4 entities in total) |
| Functional Keywords | kinase, signal transduction, cytoplasmic, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P35790 |
| Total number of polymer chains | 2 |
| Total formula weight | 105562.56 |
| Authors | Brown, K.,Hudson, C.,Charlton, P.,Pollard, J. (deposition date: 2012-01-12, release date: 2013-04-17, Last modification date: 2024-02-28) |
| Primary citation | Hudson, C.S.,Knegtel, R.M.,Brown, K.,Charlton, P.A.,Pollard, J.R. Kinetic and mechanistic characterisation of Choline Kinase-alpha. Biochim.Biophys.Acta, 1834:1107-1116, 2013 Cited by PubMed: 23416529DOI: 10.1016/j.bbapap.2013.02.008 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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