4DA5

Choline Kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Choline kinase alpha	polymer	457	52310.9	2	UniProt (P35790) Pfam (PF01633)	Homo sapiens (human)	CK, CHETK-alpha, Ethanolamine kinase;, EK
2	C, E (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	D, F (A, B)	(3R)-1-azabicyclo[2.2.2]oct-3-yl[bis(5-chlorothiophen-2-yl)]methanol	non-polymer		374.3	2	Chemie (0H7)
4	G, H (A, B)	water	water		18.0	229	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	104621.7
Non-Polymers*	Number of molecules	4
	Total formula weight	940.8
All*	Total formula weight	105562.6

*Water molecules are not included.