4DA5
Choline Kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Choline kinase alpha | polymer | 457 | 52310.9 | 2 | UniProt (P35790) Pfam (PF01633) In PDB | Homo sapiens (human) | CK, CHETK-alpha, Ethanolamine kinase;, EK |
2 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
3 | A, B | (3R)-1-azabicyclo[2.2.2]oct-3-yl[bis(5-chlorothiophen-2-yl)]methanol | non-polymer | 374.3 | 2 | Chemie (0H7) | |||
4 | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 104621.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 940.8 | |
All* | Total formula weight | 105562.6 |