4D4L
human PFKFB3 in complex with a pyrrolopyrimidone compound
Summary for 4D4L
Entry DOI | 10.2210/pdb4d4l/pdb |
Related | 4D4J 4D4K 4D4M |
Descriptor | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, PHOSPHONIC ACID, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | transferase, sugar kinase, warburg effect, oncology |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 52825.32 |
Authors | Stgallay, S.A.,Bennett, N.,Critchlow, S.,Davies, G.,Debreczeni, J.E.,Evans, N.,Holdgate, G.,Jones, N.P.,Leach, L.,Maman, S.,McLoughlin, S.,Preston, M.,Rigoreau, L.,Thomas, A.,Walker, G.,Walsch, J.,Ward, R.A.,Wheatley, E.,Winter, J. (deposition date: 2014-10-29, release date: 2016-01-20, Last modification date: 2024-05-08) |
Primary citation | Stgallay, S.A.,Bennett, N.,Critchlow, S.,Davies, G.,Debreczeni, J.E.,Evans, N.,Holdgate, G.,Jones, N.P.,Leach, L.,Maman, S.,Mcloughlin, S.,Preston, M.,Rigoreau, L.,Thomas, A.,Walker, G.,Walsch, J.,Ward, R.A.,Wheatley, E.,Winter, J. Identifying a Novel Series of Pfkfb3 Inhibitors as a Metabolic Approach to Treating Cancer from Hts, Biophysical and Biochemical Methods To be Published, |
Experimental method | X-RAY DIFFRACTION (3.16 Å) |
Structure validation
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