4D4L

human PFKFB3 in complex with a pyrrolopyrimidone compound

Summary for 4D4L

Entry DOI	10.2210/pdb4d4l/pdb
Related	4D4J 4D4K 4D4M
Descriptor	6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, PHOSPHONIC ACID, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	transferase, sugar kinase, warburg effect, oncology
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	52825.32
Authors	Stgallay, S.A.,Bennett, N.,Critchlow, S.,Davies, G.,Debreczeni, J.E.,Evans, N.,Holdgate, G.,Jones, N.P.,Leach, L.,Maman, S.,McLoughlin, S.,Preston, M.,Rigoreau, L.,Thomas, A.,Walker, G.,Walsch, J.,Ward, R.A.,Wheatley, E.,Winter, J. (deposition date: 2014-10-29, release date: 2016-01-20, Last modification date: 2020-07-29)
Primary citation	Stgallay, S.A.,Bennett, N.,Critchlow, S.,Davies, G.,Debreczeni, J.E.,Evans, N.,Holdgate, G.,Jones, N.P.,Leach, L.,Maman, S.,Mcloughlin, S.,Preston, M.,Rigoreau, L.,Thomas, A.,Walker, G.,Walsch, J.,Ward, R.A.,Wheatley, E.,Winter, J. Identifying a Novel Series of Pfkfb3 Inhibitors as a Metabolic Approach to Treating Cancer from Hts, Biophysical and Biochemical Methods To be Published,
Experimental method	X-RAY DIFFRACTION (3.16 Å)

Structure validation