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4D4L

human PFKFB3 in complex with a pyrrolopyrimidone compound

Summary for 4D4L
Entry DOI10.2210/pdb4d4l/pdb
Related4D4J 4D4K 4D4M
Descriptor6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, PHOSPHONIC ACID, PHOSPHATE ION, ... (6 entities in total)
Functional Keywordstransferase, sugar kinase, warburg effect, oncology
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight52825.32
Authors
Primary citationStgallay, S.A.,Bennett, N.,Critchlow, S.,Davies, G.,Debreczeni, J.E.,Evans, N.,Holdgate, G.,Jones, N.P.,Leach, L.,Maman, S.,Mcloughlin, S.,Preston, M.,Rigoreau, L.,Thomas, A.,Walker, G.,Walsch, J.,Ward, R.A.,Wheatley, E.,Winter, J.
Identifying a Novel Series of Pfkfb3 Inhibitors as a Metabolic Approach to Treating Cancer from Hts, Biophysical and Biochemical Methods
To be Published,
Experimental method
X-RAY DIFFRACTION (3.16 Å)
Structure validation

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PDB entries from 2024-11-06

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