4D4L
human PFKFB3 in complex with a pyrrolopyrimidone compound
Functional Information from GO Data
Functional Information from PROSITE/UniProt
site_id | PS00175 |
Number of Residues | 10 |
Details | PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LcRHGEnEhN |
Chain | Residue | Details |
A | LEU250-ASN259 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000255 |
Chain | Residue | Details |
A | ASP124 | |
A | CYS154 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000269|PubMed:22275052 |
Chain | Residue | Details |
A | HIS253 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22275052 |
Chain | Residue | Details |
A | GLU322 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16316985, ECO:0000269|PubMed:17499765, ECO:0000269|PubMed:22275052 |
Chain | Residue | Details |
A | GLY41 | |
A | ASN163 | |
A | TYR424 |
site_id | SWS_FT_FI5 |
Number of Residues | 7 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16316985 |
Chain | Residue | Details |
A | ARG74 | |
A | ARG98 | |
A | THR126 | |
A | ARG132 | |
A | LYS168 | |
A | ARG189 | |
A | TYR193 |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:25849762 |
Chain | Residue | Details |
A | ARG252 | |
A | ASN259 | |
A | GLY265 | |
A | TYR333 | |
A | ARG347 | |
A | LYS351 | |
A | TYR362 | |
A | GLN388 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P07953 |
Chain | Residue | Details |
A | TYR344 | |
A | ARG392 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:22275052 |
Chain | Residue | Details |
A | ARG252 | |
A | ASN259 | |
A | HIS387 |