4CWY

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-(5-(((3R,4R)-4-((6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL) PYRROLIDIN-3-YL)OXY)PENTYL)-4-METHYLPYRIDIN-2-AMINE

4CWY の概要

• エントリーDOI: 10.2210/pdb4cwy/pdb
• 関連するPDBエントリー: 4CWV 4CWW 4CWX 4CWZ 4CX0 4CX1 4CX2 4CX3 4CX4 4CX5 4CX6 4CX7
• 分子名称: NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, nitric oxide synthase, inhibitor complex
• 由来する生物種: BOS TAURUS (CATTLE)
• 細胞内の位置: Cell membrane: P29473
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102238.14

構造登録者

Li, H.,Poulos, T.L. (登録日: 2014-04-03, 公開日: 2014-08-13, 最終更新日: 2014-09-03)

• 主引用文献: Li, H.,Jamal, J.,Delker, S.L.,Plaza, C.,Ji, H.,Jing, Q.,Huang, H.,Kang, S.,Silverman, R.B.,Poulos, T.L.; Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases.; Biochemistry, 53:5272-, 2014; PubMed: 25089924; DOI: 10.1021/BI500561H

実験手法

X-RAY DIFFRACTION (2.15 Å)