4CV9

MPS1 kinase with 3-aminopyridin-2-one inhibitors

Summary for 4CV9

• Entry DOI: 10.2210/pdb4cv9/pdb
• Related: 4CV8 4CVA
• Descriptor: DUAL SPECIFICITY PROTEIN KINASE TTK, 4-(4-Methylpiperazin-1-yl)-N-(2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin-3-yl)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: transferase, inhibitor
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 36973.16

Authors

Fearon, D.,Bavetsias, V.,Bayliss, R.,Schmitt, J.,Westwood, I.M.,vanMontfort, R.L.M.,Jones, K. (deposition date: 2014-03-24, release date: 2015-04-08, Last modification date: 2023-12-20)

• Primary citation: Fearon, D.,Bavetsias, V.,Bayliss, R.,Schmitt, J.,Westwood, I.M.,Van Montfort, R.L.M.,Jones, K.; Protein Kinase Selectivity of a 3-Aminopyridin-2- One Based Fragment Library, Identification of 3-Amino-5-(Pyridin-4-Yl)Pyridin-2(1H)-One as a Novel Scaffold for Mps1 Inhibition; To be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)