4CV9
MPS1 kinase with 3-aminopyridin-2-one inhibitors
Summary for 4CV9
Entry DOI | 10.2210/pdb4cv9/pdb |
Related | 4CV8 4CVA |
Descriptor | DUAL SPECIFICITY PROTEIN KINASE TTK, 4-(4-Methylpiperazin-1-yl)-N-(2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin-3-yl)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | transferase, inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 36973.16 |
Authors | Fearon, D.,Bavetsias, V.,Bayliss, R.,Schmitt, J.,Westwood, I.M.,vanMontfort, R.L.M.,Jones, K. (deposition date: 2014-03-24, release date: 2015-04-08, Last modification date: 2023-12-20) |
Primary citation | Fearon, D.,Bavetsias, V.,Bayliss, R.,Schmitt, J.,Westwood, I.M.,Van Montfort, R.L.M.,Jones, K. Protein Kinase Selectivity of a 3-Aminopyridin-2- One Based Fragment Library, Identification of 3-Amino-5-(Pyridin-4-Yl)Pyridin-2(1H)-One as a Novel Scaffold for Mps1 Inhibition To be Published, |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report