4CU4

FhuA from E. coli in complex with the lasso peptide microcin J25 (MccJ25)

4CU4 の概要

• エントリーDOI: 10.2210/pdb4cu4/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000184
• 分子名称: FERRICHROME-IRON RECEPTOR, PHOSPHATE ION, MICROCIN J25, ... (11 entities in total)
• 機能のキーワード: transport protein-antibiotic complex, lipopolysaccharide, detergent, transport protein/antibiotic
• 由来する生物種: ESCHERICHIA COLI STR. K-12 SUBSTR. MG1655; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 88629.36

構造登録者

Mathavan, I.,Rebuffat, S.,Beis, K. (登録日: 2014-03-17, 公開日: 2014-04-09, 最終更新日: 2024-11-13)

主引用文献

Mathavan, I.,Zirah, S.,Mehmood, S.,Choudhury, H.G.,Goulard, C.,Li, Y.,Robinson, C.V.,Rebuffat, S.,Beis, K.
Structural Basis for Hijacking Siderophore Receptors by Antimicrobial Lasso Peptides.
Nat.Chem.Biol., 10:340-, 2014

PubMed Abstract: The lasso peptide microcin J25 is known to hijack the siderophore receptor FhuA for initiating internalization. Here, we provide what is to our knowledge the first structural evidence on the recognition mechanism, and our biochemical data show that another closely related lasso peptide cannot interact with FhuA. Our work provides an explanation on the narrow activity spectrum of lasso peptides and opens the path to the development of new antibacterials.

PubMed: 24705590
DOI: 10.1038/NCHEMBIO.1499

実験手法

X-RAY DIFFRACTION (2.3 Å)