4CL1

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors

Summary for 4CL1

Entry DOI	10.2210/pdb4cl1/pdb
Descriptor	NON-STRUCTURAL PROTEIN 5A, ZINC ION, SULFATE ION (3 entities in total)
Functional Keywords	viral protein
Biological source	HEPATITIS C VIRUS (ISOLATE H77)
Total number of polymer chains	4
Total formula weight	79680.25
Authors	Lambert, S.M.,Langley, D.R.,Garnett, J.A.,Angell, R.,Hedgethorne, K.,Meanwell, N.A.,Matthews, S.J. (deposition date: 2014-01-10, release date: 2014-04-02, Last modification date: 2023-12-20)
Primary citation	Lambert, S.M.,Langley, D.R.,Garnett, J.A.,Angell, R.,Hedgethorne, K.,Meanwell, N.A.,Matthews, S.J. The Crystal Structure of Ns5A Domain 1 from Genotype 1A Reveals New Clues to the Mechanism of Action for Dimeric Hcv Inhibitors. Protein Sci., 23:723-, 2014 Cited by PubMed: 24639329 DOI: 10.1002/PRO.2456 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation