4CJX

The crystal structure of Trypanosoma brucei N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) complexed with NADP cofactor and inhibitor

Summary for 4CJX

Entry DOI	10.2210/pdb4cjx/pdb
Descriptor	C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	oxidoreductase
Biological source	TRYPANOSOMA BRUCEI BRUCEI STRAIN 927/4 GUTAT10.1
Total number of polymer chains	2
Total formula weight	70524.28
Authors	Eadsforth, T.C.,Hunter, W.N. (deposition date: 2013-12-23, release date: 2015-02-04, Last modification date: 2023-12-20)
Primary citation	Eadsforth, T.C.,Pinto, A.,Luciani, R.,Tamborini, L.,Cullia, G.,De Micheli, C.,Marinelli, L.,Cosconati, S.,Novellino, E.,Lo Presti, L.,Cordeiro Da Silva, A.,Conti, P.,Hunter, W.N.,Costi, M.P. Characterization of 2,4-Diamino-6-Oxo-1,6-Dihydropyrimidin-5-Yl Ureido Based Inhibitors of Trypanosoma Brucei Fold and Testing for Antiparasitic Activity. J.Med.Chem., 58:7938-, 2015 Cited by PubMed: 26322631 DOI: 10.1021/ACS.JMEDCHEM.5B00687 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation