4CJX
The crystal structure of Trypanosoma brucei N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) complexed with NADP cofactor and inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004477 | molecular_function | methenyltetrahydrofolate cyclohydrolase activity |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0020023 | cellular_component | kinetoplast |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004477 | molecular_function | methenyltetrahydrofolate cyclohydrolase activity |
| B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0020023 | cellular_component | kinetoplast |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1298 |
| Chain | Residue |
| A | ASP259 |
| A | HOH2171 |
| B | LYS246 |
| B | ARG251 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG A 1299 |
| Chain | Residue |
| B | HIS134 |
| B | ILE135 |
| A | VAL110 |
| A | SER114 |
| A | LEU125 |
| A | ASP173 |
| A | HOH2177 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 9L9 A 1300 |
| Chain | Residue |
| A | TYR52 |
| A | LEU55 |
| A | LYS56 |
| A | VAL99 |
| A | GLN100 |
| A | LEU101 |
| A | ASP123 |
| A | ILE174 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | PRO277 |
| A | NAP1301 |
| A | HOH2042 |
| A | HOH2046 |
| A | HOH2102 |
| A | HOH2173 |
| A | HOH2178 |
| A | HOH2179 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 9L9 B 1298 |
| Chain | Residue |
| B | ARG10 |
| B | TYR52 |
| B | LEU55 |
| B | LYS56 |
| B | VAL99 |
| B | GLN100 |
| B | LEU101 |
| B | ASP123 |
| B | ILE174 |
| B | LEU252 |
| B | PRO272 |
| B | GLY273 |
| B | GLY276 |
| B | PRO277 |
| B | HOH2031 |
| B | HOH2068 |
| B | HOH2069 |
| B | HOH2137 |
| B | HOH2139 |
| B | HOH2140 |
| B | HOH2141 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAP A 1301 |
| Chain | Residue |
| A | ASP48 |
| A | TYR52 |
| A | PRO102 |
| A | GLY170 |
| A | ARG171 |
| A | GLY172 |
| A | ILE174 |
| A | ALA175 |
| A | HIS194 |
| A | SER195 |
| A | ALA215 |
| A | ALA216 |
| A | GLY217 |
| A | GLN218 |
| A | VAL236 |
| A | GLY237 |
| A | THR238 |
| A | 9L91300 |
| A | HOH2040 |
| A | HOH2142 |
| A | HOH2180 |
| B | ARG30 |
