4CJX
The crystal structure of Trypanosoma brucei N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) complexed with NADP cofactor and inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004477 | molecular_function | methenyltetrahydrofolate cyclohydrolase activity |
A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0020023 | cellular_component | kinetoplast |
A | 0035999 | biological_process | tetrahydrofolate interconversion |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004477 | molecular_function | methenyltetrahydrofolate cyclohydrolase activity |
B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0020023 | cellular_component | kinetoplast |
B | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 1298 |
Chain | Residue |
A | ASP259 |
A | HOH2171 |
B | LYS246 |
B | ARG251 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PEG A 1299 |
Chain | Residue |
B | HIS134 |
B | ILE135 |
A | VAL110 |
A | SER114 |
A | LEU125 |
A | ASP173 |
A | HOH2177 |
site_id | AC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE 9L9 A 1300 |
Chain | Residue |
A | TYR52 |
A | LEU55 |
A | LYS56 |
A | VAL99 |
A | GLN100 |
A | LEU101 |
A | ASP123 |
A | ILE174 |
A | PRO272 |
A | GLY273 |
A | GLY276 |
A | PRO277 |
A | NAP1301 |
A | HOH2042 |
A | HOH2046 |
A | HOH2102 |
A | HOH2173 |
A | HOH2178 |
A | HOH2179 |
site_id | AC4 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 9L9 B 1298 |
Chain | Residue |
B | ARG10 |
B | TYR52 |
B | LEU55 |
B | LYS56 |
B | VAL99 |
B | GLN100 |
B | LEU101 |
B | ASP123 |
B | ILE174 |
B | LEU252 |
B | PRO272 |
B | GLY273 |
B | GLY276 |
B | PRO277 |
B | HOH2031 |
B | HOH2068 |
B | HOH2069 |
B | HOH2137 |
B | HOH2139 |
B | HOH2140 |
B | HOH2141 |
site_id | AC5 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE NAP A 1301 |
Chain | Residue |
A | ASP48 |
A | TYR52 |
A | PRO102 |
A | GLY170 |
A | ARG171 |
A | GLY172 |
A | ILE174 |
A | ALA175 |
A | HIS194 |
A | SER195 |
A | ALA215 |
A | ALA216 |
A | GLY217 |
A | GLN218 |
A | VAL236 |
A | GLY237 |
A | THR238 |
A | 9L91300 |
A | HOH2040 |
A | HOH2142 |
A | HOH2180 |
B | ARG30 |