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4CI9

Crystal structure of cathepsin A, apo-structure

Summary for 4CI9
Entry DOI10.2210/pdb4ci9/pdb
Related4CIA
DescriptorLYSOSOMAL PROTECTIVE PROTEIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... (7 entities in total)
Functional Keywordshydrolase, drug discovery, serine carboxypeptidase, cardiovascular drug, heart failure, endothelin, tetrahedral intermediate, covalent inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight53154.63
Authors
Schreuder, H.A.,Liesum, A.,Kroll, K.,Boehnisch, B.,Buning, C.,Ruf, S.,Buning, C.,Sadowski, T. (deposition date: 2013-12-06, release date: 2014-02-26, Last modification date: 2023-12-20)
Primary citationSchreuder, H.A.,Liesum, A.,Kroll, K.,Bohnisch, B.,Buning, C.,Ruf, S.,Sadowski, T.
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.
Biochem. Biophys. Res. Commun., 445:451-456, 2014
Cited by
PubMed: 24530914
DOI: 10.1016/j.bbrc.2014.02.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.58 Å)
Structure validation

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