4CFH

Structure of an active form of mammalian AMPK

Replaces:  2Y94

Summary for 4CFH

Related4CFE 4CFF
Descriptor5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ... (6 entities in total)
Functional Keywordstransferase, transferase phosphorylation, active form, nucleotide-binding, staurosporine-binding, serine/threonine-protein kinase
Biological sourceRATTUS NORVEGICUS (NORWAY RAT)
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Total number of polymer chains4
Total molecular weight108948.96
Authors
Primary citation
Xiao, B.,Sanders, M.J.,Underwood, E.,Heath, R.,Mayer, F.,Carmena, D.,Jing, C.,Walker, P.A.,Eccleston, J.F.,Haire, L.F.,Saiu, P.,Howell, S.A.,Aasland, R.,Martin, S.R.,Carling, D.,Gamblin, S.J.
Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472:230-, 2011
PubMed: 21399626 (PDB entries with the same primary citation)
DOI: 10.1038/NATURE09932
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.24 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2687 0.6% 6.5% 3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4cfh
no rotation
Molmil generated image of 4cfh
rotated about x axis by 90°
Molmil generated image of 4cfh
rotated about y axis by 90°