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4CFH

Structure of an active form of mammalian AMPK

Replaces:  2Y94
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1polymer49357248.51UniProt (P54645)
Pfam (PF00069)
Pfam (PF21147)
Pfam (PF16579)
RATTUS NORVEGICUS (NORWAY RAT)AMPK SUBUNIT ALPHA-1
2B
(B)
5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2polymer8710040.81UniProt (O43741)
Pfam (PF04739)
HOMO SAPIENS (HUMAN)
3C
(C)
5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1polymer273064.61UniProt (P54645)RATTUS NORVEGICUS (NORWAY RAT)AMPK SUBUNIT ALPHA-1
4D
(E)
5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1polymer33037434.11UniProt (P80385)
Pfam (PF00571)
RATTUS NORVEGICUS (NORWAY RAT)AMPK SUBUNIT ALPHA-1, AMPK GAMMA1, AMPK SUBUNIT GAMMA-1, AMPKG
5E
(A)
STAUROSPORINEnon-polymer466.51Chemie (STU)
6F, G
(E)
ADENOSINE MONOPHOSPHATEnon-polymer347.22Chemie (AMP)
Sequence modifications
A: 2 - 470 (UniProt: P54645)
PDBExternal DatabaseDetails
Met -18-expression tag
Ser -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
Ser -10-expression tag
Ser -9-expression tag
Gly -8-expression tag
Leu -7-expression tag
Glu -6-expression tag
Val -5-expression tag
Leu -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Pro 0-expression tag
Met 1-expression tag
Leu 471-SEE REMARK 999
Glu 472-SEE REMARK 999
Val 473-SEE REMARK 999
Leu 474-SEE REMARK 999
C: 524 - 548 (UniProt: P54645)
PDBExternal DatabaseDetails
Phe 522-SEE REMARK 999
Gln 523-SEE REMARK 999
B: 187 - 272 (UniProt: O43741)
PDBExternal DatabaseDetails
Met 186-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight107788.0
Non-Polymers*Number of molecules3
Total formula weight1161.0
All*Total formula weight108949.0
*Water molecules are not included.

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PDB entries from 2024-12-18

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