4CE2
Hsp90 N-terminal domain bound to macrolactam analogues of radicicol.
Summary for 4CE2
| Entry DOI | 10.2210/pdb4ce2/pdb |
| Related | 4CE1 4CE3 |
| Descriptor | ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (9E)-19-CHLORANYL-13-METHYL-16,18-BIS(OXIDANYL)-13-AZABICYCLO[13.4.0]NONADECA-1(15),9,16,18-TETRAENE-3,14-DIONE (3 entities in total) |
| Functional Keywords | chaperone |
| Biological source | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) |
| Cellular location | Cytoplasm : P02829 |
| Total number of polymer chains | 1 |
| Total formula weight | 24574.43 |
| Authors | Roe, S.M.,Parry-Morris, S.,Prodromou, C. (deposition date: 2013-11-08, release date: 2014-01-29, Last modification date: 2023-12-20) |
| Primary citation | Dutton, B.L.,Kitson, R.R.,Parry-Morris, S.,Roe, S.M.,Prodromou, C.,Moody, C.J. Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. Org. Biomol. Chem., 12:1328-1340, 2014 Cited by PubMed: 24435512DOI: 10.1039/c3ob42211a PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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