4CCH

Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in an open binary complex with d5SICS as templating nucleotide

Summary for 4CCH

• Entry DOI: 10.2210/pdb4cch/pdb
• Descriptor: DNA POLYMERASE I, THERMOSTABLE, 5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*DOC)-3', 5'-D(*AP*AP*CP*LHOP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP* C)-3', ... (7 entities in total)
• Functional Keywords: transferase-dna complex, unnatural nucleotide, artificial nucleotide, binary complex, klentaq, transferase/dna
• Biological source: THERMUS AQUATICUS; More
• Total number of polymer chains: 3
• Total formula weight: 69819.15

Authors

Betz, K.,Malyshev, D.A.,Lavergne, T.,Welte, W.,Diederichs, K.,Romesberg, F.E.,Marx, A. (deposition date: 2013-10-23, release date: 2013-12-11, Last modification date: 2013-12-25)

• Primary citation: Betz, K.,Malyshev, D.A.,Lavergne, T.,Welte, W.,Diederichs, K.,Romesberg, F.E.,Marx, A.; Structural Insights Into DNA Replication without Hydrogen Bonds.; J.Am.Chem.Soc., 135:18637-, 2013; PubMed: 24283923; DOI: 10.1021/JA409609J

Experimental method

X-RAY DIFFRACTION (2.55 Å)