4CB6

Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 11)

Summary for 4CB6

Entry DOI	10.2210/pdb4cb6/pdb
Related	4CB4 4CB5 4CB7
Descriptor	POLYMERASE BASIC SUBUNIT 2, 2,9-N,N-DI(4-CARBOXYBUTYL)-7-N-METHYLGUANINE, IODIDE ION, ... (4 entities in total)
Functional Keywords	transferase, influenza polymerase, m7gtp, cap-binding inhibitors
Biological source	INFLUENZA A VIRUS
Total number of polymer chains	2
Total formula weight	40158.44
Authors	Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. (deposition date: 2013-10-10, release date: 2013-10-30, Last modification date: 2023-12-20)
Primary citation	Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain J.Med.Chem., 56:8915-, 2013 Cited by PubMed: 24134208 DOI: 10.1021/JM401369Y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation