4C8B

Structure of the kinase domain of human RIPK2 in complex with ponatinib

Summary for 4C8B

• Entry DOI: 10.2210/pdb4c8b/pdb
• Descriptor: RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase, structural genomics
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm : O43353
• Total number of polymer chains: 2
• Total formula weight: 77901.12

Authors

Canning, P.,Krojer, T.,Bradley, A.,Mahajan, P.,Goubin, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2013-09-30, release date: 2013-10-16, Last modification date: 2023-12-20)

• Primary citation: Canning, P.,Ruan, Q.,Schwerd, T.,Hrdinka, M.,Maki, J.L.,Saleh, D.,Suebsuwong, C.,Ray, S.,Brennan, P.E.,Cuny, G.D.,Uhlig, H.H.,Gyrd-Hansen, M.,Degterev, A.,Bullock, A.N.; Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.; Chem. Biol., 22:1174-1184, 2015; PubMed: 26320862; DOI: 10.1016/j.chembiol.2015.07.017

Experimental method

X-RAY DIFFRACTION (2.75 Å)