4C8B

Structure of the kinase domain of human RIPK2 in complex with ponatinib

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 0LI A 1000

Chain	Residue
A	ALA45
A	TYR97
A	MET98
A	LEU143
A	HIS144
A	LEU153
A	ILE162
A	ALA163
A	ASP164
A	PHE165
A	LYS47
A	GLU66
A	LEU70
A	ILE78
A	LEU79
A	ILE93
A	THR95
A	GLU96

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 0LI B 1000

Chain	Residue
B	ALA45
B	LYS47
B	GLU66
B	LEU79
B	THR95
B	GLU96
B	TYR97
B	MET98
B	LEU143
B	HIS144
B	ILE162
B	ALA163
B	ASP164
B	PHE165

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1317

Chain	Residue
A	ARG121
A	LEU223
A	SER224

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LlHhDLKtqNILL

Chain	Residue	Details
A	LEU142-LEU154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:9705938

Chain	Residue	Details
A	ASP146
B	ASP146

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU24
B	LEU24

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	LYS47
B	LYS47

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:22520462

Chain	Residue	Details
A	THR149
A	THR189
B	THR149
B	THR189

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER168
B	SER168

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine; alternate => ECO:0000269|PubMed:28545134

Chain	Residue	Details
A	SER174
A	SER178
A	SER181
B	SER174
B	SER178
B	SER181

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis and LRRK2; alternate => ECO:0000269|PubMed:16824733, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28545134

Chain	Residue	Details
A	SER176
B	SER176

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:28545134

Chain	Residue	Details
A	SER180
B	SER180

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: (Microbial infection) O-acetylserine; by Yersinia YopJ => ECO:0000269|PubMed:22520462

Chain	Residue	Details
A	SER183
B	SER183

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18079694

Chain	Residue	Details
A	LYS209
B	LYS209

---