4C6W

Crystal structure of M. tuberculosis C171Q KasA

Summary for 4C6W

Entry DOI	10.2210/pdb4c6w/pdb
Related	4C6U 4C6V 4C6X 4C6Z 4C70 4C71 4C72 4C73
Descriptor	3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, POTASSIUM ION, (2R)-2-(hexadecanoyloxy)-3-{[(10R)-10-methyloctadecanoyl]oxy}propyl phosphate, ... (7 entities in total)
Functional Keywords	transferase, kas enzyme, condensing enzyme, type 2 fatty acid biosynthesis, mycolic acid synthesis, thiolactomycin
Biological source	MYCOBACTERIUM TUBERCULOSIS H37RV
Total number of polymer chains	2
Total formula weight	93625.02
Authors	Schiebel, J.,Kapilashrami, K.,Fekete, A.,Bommineni, G.R.,Schaefer, C.M.,Mueller, M.J.,Tonge, P.J.,Kisker, C. (deposition date: 2013-09-19, release date: 2013-10-09, Last modification date: 2023-12-20)
Primary citation	Schiebel, J.,Kapilashrami, K.,Fekete, A.,Bommineni, G.R.,Schaefer, C.M.,Mueller, M.J.,Tonge, P.J.,Kisker, C. Structural Basis for the Recognition of Mycolic Acid Precursors by Kasa, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis J.Biol.Chem., 288:34190-, 2013 Cited by PubMed: 24108128 DOI: 10.1074/JBC.M113.511436 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation