4C6Q

Crystal structure of the dihydroorotase domain of human CAD C1613S mutant bound to substrate at pH 7.0

Summary for 4C6Q

Related4C6B 4C6C 4C6D 4C6E 4C6F 4C6I 4C6J 4C6K 4C6L 4C6M 4C6N 4C6O 4C6P
DescriptorCAD PROTEIN, OROTIC ACID, ZINC ION, ... (6 entities in total)
Functional Keywordshydrolase, de novo pyrimidine biosynthesis, amidohydrolase superfamily, metalloenzyme, zinc binding, histidinate anion
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P27708
Total number of polymer chains1
Total molecular weight43547.09
Authors
Ramon-Maiques, S.,Lallous, N.,Grande-Garcia, A. (deposition date: 2013-09-18, release date: 2014-02-05, Last modification date: 2014-02-19)
Primary citation
Grande-Garcia, A.,Lallous, N.,Diaz-Tejada, C.,Ramon-Maiques, S.
Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22:185-, 2014
PubMed: 24332717 (PDB entries with the same primary citation)
DOI: 10.1016/J.STR.2013.10.016
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.659 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.16130.6%2.0%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution