4C6D
Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 6.0
Summary for 4C6D
| Entry DOI | 10.2210/pdb4c6d/pdb |
| Related | 4C6B 4C6C 4C6E 4C6F 4C6I 4C6J 4C6K 4C6L 4C6M 4C6N 4C6O 4C6P 4C6Q |
| Descriptor | CAD PROTEIN, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, N-CARBAMOYL-L-ASPARTATE, ... (6 entities in total) |
| Functional Keywords | hydrolase, de novo pyrimidine biosynthesis, amidohydrolase superfamily, metalloenzyme, zinc binding, histidinate anion |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Cytoplasm: P27708 |
| Total number of polymer chains | 1 |
| Total formula weight | 43695.99 |
| Authors | Ramon-Maiques, S.,Lallous, N.,Grande-Garcia, A. (deposition date: 2013-09-18, release date: 2014-02-05, Last modification date: 2023-12-20) |
| Primary citation | Grande-Garcia, A.,Lallous, N.,Diaz-Tejada, C.,Ramon-Maiques, S. Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad. Structure, 22:185-, 2014 Cited by PubMed: 24332717DOI: 10.1016/J.STR.2013.10.016 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.298 Å) |
Structure validation
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