4C4N

Crystal structure of the Sonic Hedgehog-heparin complex

Summary for 4C4N

• Entry DOI: 10.2210/pdb4c4n/pdb
• Related: 4C4M
• Descriptor: SONIC HEDGEHOG PROTEIN, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: signaling protein, hedgehog signalling, morphogens, heparan sulphate proteoglycans, glycosaminoglycans
• Biological source: MUS MUSCULUS (HOUSE MOUSE)
• Total number of polymer chains: 2
• Total formula weight: 41363.47

Authors

Whalen, D.M.,Malinauskas, T.,Gilbert, R.J.C.,Siebold, C. (deposition date: 2013-09-05, release date: 2013-10-02, Last modification date: 2020-07-29)

• Primary citation: Whalen, D.M.,Malinauskas, T.,Gilbert, R.J.C.,Siebold, C.; Structural Insights Into Proteoglycan-Shaped Hedgehog Signaling.; Proc.Natl.Acad.Sci.USA, 110:16420-, 2013; PubMed: 24062467; DOI: 10.1073/PNAS.1310097110

Experimental method

X-RAY DIFFRACTION (2.36 Å)