4C3P
Structure of dephosphorylated Aurora A (122-403) bound to TPX2 and AMPPCP
Summary for 4C3P
| Entry DOI | 10.2210/pdb4c3p/pdb |
| Related | 4C3R |
| Descriptor | AURORA KINASE A, TARGETING PROTEIN FOR XKLP2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total) |
| Functional Keywords | transferase, activation, allostery, cell cycle, cancer |
| Biological source | HOMO SAPIENS (HUMAN) More |
| Total number of polymer chains | 4 |
| Total formula weight | 76339.62 |
| Authors | Zorba, A.,Kutter, S.,Kern, D. (deposition date: 2013-08-26, release date: 2014-05-28, Last modification date: 2023-12-20) |
| Primary citation | Zorba, A.,Buosi, V.,Kutter, S.,Kern, N.,Pontiggia, F.,Cho, Y.J.,Kern, D. Molecular Mechanism of Aurora a Kinase Autophosphorylation and its Allosteric Activation by Tpx2. Elife, 3:02667-, 2014 Cited by PubMed: 24867643DOI: 10.7554/ELIFE.02667 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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