4C38
PKA-S6K1 Chimera with compound 21e (CCT239066) bound
Summary for 4C38
Entry DOI | 10.2210/pdb4c38/pdb |
Related | 4C33 4C34 4C35 4C36 4C37 |
Descriptor | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR PEPTIDE, 4-(1-ethyl-6-methyl-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine, ... (5 entities in total) |
Functional Keywords | transferase-inhibitor complex, transferase/inhibitor |
Biological source | BOS TAURUS (BOVINE) More |
Total number of polymer chains | 2 |
Total formula weight | 43515.45 |
Authors | Couty, S.,Westwood, I.M.,Kalusa, A.,Cano, C.,Travers, J.,Boxall, K.,Chow, C.L.,Burns, S.,Schmitt, J.,Pickard, L.,Barillari, C.,McAndrew, P.C.,Clarke, P.A.,Linardopoulos, S.,Griffin, R.J.,Aherne, G.W.,Raynaud, F.I.,Workman, P.,Jones, K.,van Montfort, R.L.M. (deposition date: 2013-08-21, release date: 2013-10-09, Last modification date: 2023-12-20) |
Primary citation | Couty, S.,Westwood, I.M.,Kalusa, A.,Cano, C.,Travers, J.,Boxall, K.,Chow, C.L.,Burns, S.,Schmitt, J.,Pickard, L.,Barillari, C.,McAndrew, P.C.,Clarke, P.A.,Linardopoulos, S.,Griffin, R.J.,Aherne, G.W.,Raynaud, F.I.,Workman, P.,Jones, K.,van Montfort, R.L. The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget, 4:1647-1661, 2013 Cited by PubMed: 24072592DOI: 10.18632/oncotarget.1255 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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