4C34
PKA-S6K1 Chimera with Staurosporine bound
Summary for 4C34
Entry DOI | 10.2210/pdb4c34/pdb |
Related | 4C33 4C35 4C36 4C37 4C38 |
Descriptor | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, STAUROSPORINE, ... (6 entities in total) |
Functional Keywords | transferase-inhibitor complex, transferase/inhibitor |
Biological source | BOS TAURUS (BOVINE) More |
Total number of polymer chains | 2 |
Total formula weight | 43881.85 |
Authors | Couty, S.,Westwood, I.M.,Kalusa, A.,Cano, C.,Travers, J.,Boxall, K.,Chow, C.L.,Burns, S.,Schmitt, J.,Pickard, L.,Barillari, C.,McAndrew, P.C.,Clarke, P.A.,Linardopoulos, S.,Griffin, R.J.,Aherne, G.W.,Raynaud, F.I.,Workman, P.,Jones, K.,van Montfort, R.L.M. (deposition date: 2013-08-21, release date: 2013-10-09, Last modification date: 2023-12-20) |
Primary citation | Couty, S.,Westwood, I.M.,Kalusa, A.,Cano, C.,Travers, J.,Boxall, K.,Chow, C.L.,Burns, S.,Schmitt, J.,Pickard, L.,Barillari, C.,McAndrew, P.C.,Clarke, P.A.,Linardopoulos, S.,Griffin, R.J.,Aherne, G.W.,Raynaud, F.I.,Workman, P.,Jones, K.,van Montfort, R.L. The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget, 4:1647-1661, 2013 Cited by PubMed: 24072592DOI: 10.18632/oncotarget.1255 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)