4C34
PKA-S6K1 Chimera with Staurosporine bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA | polymer | 351 | 41028.6 | 1 | UniProt (P00517) Pfam (PF00069) | BOS TAURUS (BOVINE) | PKA C-ALPHA |
| 2 | B (I) | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA | polymer | 18 | 1973.2 | 1 | UniProt (Q3SX13) | BOS TAURUS | PKI-ALPHA |
| 3 | C (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) PubChem (71203703) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (42610657) PubChem (44299148) PubChem (358479) PubChem (49831000) PubChem (5280487) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (12046017) PubChem (68262703) PubChem (68306294) PubChem (73953205) PubChem (86306248) PubChem (122130844) PubChem (5279) PubChem (44259) PubChem (451705) PubChem (5459111) PubChem (6419748) PubChem (9804568) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 5 | E (A) | N-OCTANOYL-N-METHYLGLUCAMINE | non-polymer | 321.4 | 1 | Chemie (MG8) PubChem (160091) PubChem (52941987) PubChem (53393753) PubChem (11278683) PubChem (95566078) PubChem (95566079) PubChem (99722591) PubChem (101086767) PubChem (124826259) PubChem (4377671) PubChem (163954134) | |||
| 6 | F, G (A, I) | water | water | 18.0 | 379 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Tyr 54 | Phe 55 | engineered mutation |
| Leu 120 | Met 121 | engineered mutation |
| Leu 123 | Val 124 | engineered mutation |
| Met 173 | Leu 174 | engineered mutation |
| Lys 181 | Gln 182 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43001.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 880.0 | |
| All* | Total formula weight | 43881.9 |
