4C36

PKA-S6K1 Chimera with compound 15e (CCT147581) bound

Summary for 4C36

• Entry DOI: 10.2210/pdb4c36/pdb
• Related: 4C33 4C34 4C35 4C37 4C38
• Descriptor: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, 4-[1-(cyclopropylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine, ... (5 entities in total)
• Functional Keywords: transferase-inhibitor complex, chimera, s6k1, transferase/inhibitor
• Biological source: BOS TAURUS (BOVINE); More
• Total number of polymer chains: 2
• Total formula weight: 43542.37

Authors

Couty, S.,Westwood, I.M.,Kalusa, A.,Cano, C.,Travers, J.,Boxall, K.,Chow, C.L.,Burns, S.,Schmitt, J.,Pickard, L.,Barillari, C.,McAndrew, P.C.,Clarke, P.A.,Linardopoulos, S.,Griffin, R.J.,Aherne, G.W.,Raynaud, F.I.,Workman, P.,Jones, K.,van Montfort, R.L.M. (deposition date: 2013-08-21, release date: 2013-10-09, Last modification date: 2023-12-20)

• Primary citation: Couty, S.,Westwood, I.M.,Kalusa, A.,Cano, C.,Travers, J.,Boxall, K.,Chow, C.L.,Burns, S.,Schmitt, J.,Pickard, L.,Barillari, C.,McAndrew, P.C.,Clarke, P.A.,Linardopoulos, S.,Griffin, R.J.,Aherne, G.W.,Raynaud, F.I.,Workman, P.,Jones, K.,van Montfort, R.L.; The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design.; Oncotarget, 4:1647-1661, 2013; PubMed: 24072592; DOI: 10.18632/oncotarget.1255

Experimental method

X-RAY DIFFRACTION (1.98 Å)