4C38
PKA-S6K1 Chimera with compound 21e (CCT239066) bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA | polymer | 351 | 40948.7 | 1 | UniProt (P00517) Pfam (PF00069) | BOS TAURUS (BOVINE) | PKA C-ALPHA |
| 2 | B (I) | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR PEPTIDE | polymer | 20 | 2226.4 | 1 | UniProt (by SIFTS) (Q3SX13) | BOS TAURUS | |
| 3 | C (A) | 4-(1-ethyl-6-methyl-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine | non-polymer | 244.3 | 1 | Chemie (VUP) | |||
| 4 | D, E, F (A) | METHANOL | non-polymer | 32.0 | 3 | Chemie (MOH) | |||
| 5 | G, H (A, I) | water | water | 18.0 | 633 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Tyr 54 | Phe 55 | engineered mutation |
| Leu 120 | Met 121 | engineered mutation |
| Leu 123 | Val 124 | engineered mutation |
| Met 173 | Leu 174 | engineered mutation |
| Lys 181 | Gln 182 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43175.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 340.4 | |
| All* | Total formula weight | 43515.5 |
