4C38

PKA-S6K1 Chimera with compound 21e (CCT239066) bound

4C38 の概要

• エントリーDOI: 10.2210/pdb4c38/pdb
• 関連するPDBエントリー: 4C33 4C34 4C35 4C36 4C37
• 分子名称: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR PEPTIDE, 4-(1-ethyl-6-methyl-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine, ... (5 entities in total)
• 機能のキーワード: transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: BOS TAURUS (BOVINE); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43515.45

構造登録者

Couty, S.,Westwood, I.M.,Kalusa, A.,Cano, C.,Travers, J.,Boxall, K.,Chow, C.L.,Burns, S.,Schmitt, J.,Pickard, L.,Barillari, C.,McAndrew, P.C.,Clarke, P.A.,Linardopoulos, S.,Griffin, R.J.,Aherne, G.W.,Raynaud, F.I.,Workman, P.,Jones, K.,van Montfort, R.L.M. (登録日: 2013-08-21, 公開日: 2013-10-09, 最終更新日: 2023-12-20)

• 主引用文献: Couty, S.,Westwood, I.M.,Kalusa, A.,Cano, C.,Travers, J.,Boxall, K.,Chow, C.L.,Burns, S.,Schmitt, J.,Pickard, L.,Barillari, C.,McAndrew, P.C.,Clarke, P.A.,Linardopoulos, S.,Griffin, R.J.,Aherne, G.W.,Raynaud, F.I.,Workman, P.,Jones, K.,van Montfort, R.L.; The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design.; Oncotarget, 4:1647-1661, 2013; PubMed: 24072592; DOI: 10.18632/oncotarget.1255

実験手法

X-RAY DIFFRACTION (1.58 Å)