4C02

Crystal structure of human ACVR1 (ALK2) in complex with FKBP12.6 and dorsomorphin

Summary for 4C02

DescriptorACTIVIN RECEPTOR TYPE-1, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B, CITRATE ANION, ... (6 entities in total)
Functional Keywordstransferase-isomerase complex, transferase, dorsomorphin, transferase/isomerase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationMembrane; Single-pass type I membrane protein Q04771
Cytoplasm  P68106
Total number of polymer chains2
Total molecular weight51916.42
Authors
Williams, E.,Riesebos, E.,Vollmar, M.,Krojer, T.,Bradley, A.,Shrestha, L.,Kupinska, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2013-07-31, release date: 2013-08-07, Last modification date: 2018-01-24)
Primary citation
Williams, E.,Riesebos, E.,Vollmar, M.,Krojer, T.,Bradley, A.,Shrestha, L.,Kupinska, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.
Crystal Structure of Human Acvr1 (Alk2) in Complex with Fkbp12.6 And Dorsomorphin
Ph D Thesis,
Experimental method
X-RAY DIFFRACTION (2.17 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20250.2%1.4%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4c02
no rotation
Molmil generated image of 4c02
rotated about x axis by 90°
Molmil generated image of 4c02
rotated about y axis by 90°