4C02
Crystal structure of human ACVR1 (ALK2) in complex with FKBP12.6 and dorsomorphin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ACTIVIN RECEPTOR TYPE-1 | polymer | 330 | 37398.7 | 1 | UniProt (Q04771) Pfam (PF08515) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | ACTIVIN RECEPTOR TYPE I, ACTR-I, ACTIVIN RECEPTOR-LIKE KINA SE 2, ALK-2, SERINE/THREONINE-PROTEIN KINASE RECEPTOR R1, SKR1, TG F-B SUPERFAMILY RECEPTOR TYPE I, TSR-I, ACVR1A |
| 2 | B (B) | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B | polymer | 108 | 11798.5 | 1 | UniProt (P68106) Pfam (PF00254) | HOMO SAPIENS (HUMAN) | PPIASE FKBP1B, 12.6 KDA FK506-BINDING PROTEIN, 12.6 KDA FKB P, FKBP-12.6, FK506-BINDING PROTEIN 1B, FKBP-1B, IMMUNOPHILIN FKBP 12.6, ROTAMASE, H-FKBP-12, FKBP1B |
| 3 | C, D, E, F, G... (A, B) | CITRATE ANION | non-polymer | 189.1 | 8 | Chemie (FLC) | |||
| 4 | J (A) | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | non-polymer | 399.5 | 1 | Chemie (TAK) | |||
| 5 | K, L, M, N, O... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 6 | Y, Z (A, B) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A: 172 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 170 | - | expression tag |
| Met 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49197.2 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2719.2 | |
| All* | Total formula weight | 51916.4 |
