4BZC
Crystal structure of the tetrameric dGTP-bound wild type SAMHD1 catalytic core
Summary for 4BZC
Entry DOI | 10.2210/pdb4bzc/pdb |
Related | 4BZB |
Descriptor | DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1, 2'-deoxyguanosine-5'-O-(1-thiotriphosphate), MANGANESE (II) ION, ... (5 entities in total) |
Functional Keywords | hydrolase, hiv restriction factor, dntpase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: Q9Y3Z3 |
Total number of polymer chains | 4 |
Total formula weight | 260229.22 |
Authors | Ji, X.,Yang, H.,Wu, Y.,Yan, J.,Mehrens, J.,DeLucia, M.,Hao, C.,Gronenborn, A.M.,Skowronski, J.,Ahn, J.,Xiong, Y. (deposition date: 2013-07-25, release date: 2013-10-23, Last modification date: 2023-12-20) |
Primary citation | Ji, X.,Wu, Y.,Yan, J.,Mehrens, J.,Yang, H.,Delucia, M.,Hao, C.,Gronenborn, A.M.,Skowronski, J.,Ahn, J.,Xiong, Y. Mechanism of Allosteric Activation of Samhd1 by Dgtp Nat.Struct.Mol.Biol., 20:1304-, 2013 Cited by PubMed: 24141705DOI: 10.1038/NSMB.2692 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.88 Å) |
Structure validation
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