4BVG

CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH NATIVE ALKYLIMIDATE FORMED FROM ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527

Summary for 4BVG

Entry DOI	10.2210/pdb4bvg/pdb
Related	4BUZ 4BV2 4BV3 4BVB 4BVE 4BVF 4BVH
Descriptor	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL, 1,2-ETHANEDIOL, ... (9 entities in total)
Functional Keywords	hydrolase-ligase complex, nad-dependent deacetylase, native intermediate, hydrolase/ligase
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	34367.48
Authors	Nguyen, G.T.T.,Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-06-25, release date: 2013-07-17, Last modification date: 2023-12-20)
Primary citation	Gertz, M.,Fischer, F.,Nguyen, G.T.,Lakshminarasimhan, M.,Schutkowski, M.,Weyand, M.,Steegborn, C. Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc. Natl. Acad. Sci. U.S.A., 110:E2772-E2781, 2013 Cited by PubMed: 23840057 DOI: 10.1073/pnas.1303628110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation