4BVG
CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH NATIVE ALKYLIMIDATE FORMED FROM ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL | polymer | 284 | 31484.2 | 1 | UniProt (Q9NTG7) Pfam (PF02146) In PDB | HOMO SAPIENS (HUMAN) | SIRT3, HSIRT3, REGULATORY PROTEIN SIR2 HOMOLOG 3, SIR2-LIKE PROTEIN 3 |
| 2 | B | ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL | polymer | 10 | 1207.5 | 1 | UniProt (Q9NUB1) In PDB | HOMO SAPIENS | ACETYL-LYSINE ACS2-PEPTIDE, ACETATE--COA LIGASE 2, ACETYL-C ACECS2, ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 1 |
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 8 | B | (2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE | non-polymer | 601.4 | 1 | Chemie (XYQ) | |||
| 9 | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32691.7 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1675.8 | |
| All* | Total formula weight | 34367.5 |
