4BVE

CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE

Summary for 4BVE

• Entry DOI: 10.2210/pdb4bve/pdb
• Related: 4BUZ 4BV2 4BV3 4BVB 4BVF 4BVG 4BVH
• Descriptor: NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL, ZINC ION, ... (8 entities in total)
• Functional Keywords: hydrolase-ligase complex, thio-intermediate, hydrolase/ligase
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Mitochondrion matrix: Q9NTG7 Q9NUB1
• Total number of polymer chains: 2
• Total formula weight: 33655.22

Authors

Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-06-25, release date: 2013-07-17, Last modification date: 2023-12-20)

• Primary citation: Gertz, M.,Fischer, F.,Nguyen, G.T.T.,Lakshminarasimhan, M.,Schutkowski, M.,Weyand, M.,Steegborn, C.; Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism; Proc.Natl.Acad.Sci.USA, 110:E2772-, 2013; PubMed: 23840057; DOI: 10.1073/PNAS.1303628110

Experimental method

X-RAY DIFFRACTION (2.05 Å)