4BUZ

SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD

4BUZ の概要

• エントリーDOI: 10.2210/pdb4buz/pdb
• 関連するPDBエントリー: 4BV2 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH
• 分子名称: NAD-DEPENDENT PROTEIN DEACETYLASE, CELLULAR TUMOR ANTIGEN P53, (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide, ... (8 entities in total)
• 機能のキーワード: hydrolase, nad-dependent deacetylase, sirtuin, inhibitor complex, ex-527, running reaction
• 由来する生物種: THERMOTOGA MARITIMA; 詳細
• 細胞内の位置: Cytoplasm (By similarity): Q9WYW0; Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30344.21

構造登録者

Weyand, M.,Lakshminarasimhan, M.,Gertz, M.,Steegborn, C. (登録日: 2013-06-24, 公開日: 2013-07-17, 最終更新日: 2023-12-20)

• 主引用文献: Gertz, M.,Fischer, F.,Nguyen, G.T.T.,Lakshminarasimhan, M.,Schutkowski, M.,Weyand, M.,Steegborn, C.; Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism; Proc.Natl.Acad.Sci.USA, 110:E2772-, 2013; PubMed: 23840057; DOI: 10.1073/PNAS.1303628110

実験手法

X-RAY DIFFRACTION (1.9 Å)