4BRX

Focal Adhesion Kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor

Summary for 4BRX

Entry DOI	10.2210/pdb4brx/pdb
Descriptor	FOCAL ADHESION KINASE 1, 2-(4-(2-methoxy-4-morpholinophenylamino)-1,3,5-triazin-2-ylamino)-N-methylbenzamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	transferase, kinase inhibitor, atp-binding, integrin signaling
Biological source	GALLUS GALLUS (CHICKEN)
Total number of polymer chains	1
Total formula weight	32263.35
Authors	Le Coq, J.,Lietha, D. (deposition date: 2013-06-05, release date: 2013-07-24, Last modification date: 2023-12-20)
Primary citation	Dao, P.,Jarray, R.,Le Coq, J.,Lietha, D.,Loukaci, A.,Lepelletier, Y.,Hadj-Slimane, R.,Garbay, C.,Raynaud, F.,Chen, H. Synthesis of Novel Diarylamino-1,3,5-Triazine Derivatives as Fak Inhibitors with Anti-Angiogenic Activity. Bioorg.Med.Chem.Lett., 23:4552-, 2013 Cited by PubMed: 23845217 DOI: 10.1016/J.BMCL.2013.06.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation