4BQH

Crystal structure of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei in complex with inhibitor

4BQH の概要

• エントリーDOI: 10.2210/pdb4bqh/pdb
• 分子名称: UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE, SULFATE ION, (3S)-3-[2-(1,3-benzodioxol-5-yl)-2-oxidanylidene-ethyl]-4-bromanyl-5-methyl-3-oxidanyl-1H-indol-2-one, ... (4 entities in total)
• 機能のキーワード: transferase, inhibitor
• 由来する生物種: TRYPANOSOMA BRUCEI
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61195.09

構造登録者

Fang, W.,Raimi, O.G.,vanAalten, D.M.F. (登録日: 2013-05-30, 公開日: 2013-07-17, 最終更新日: 2023-12-20)

• 主引用文献: Urbaniak, M.D.,Collie, I.T.,Fang, W.,Aristotelous, T.,Eskilsson, S.,Raimi, O.G.,Harrison, J.,Hopkins Navratolova, I.,Frearson, J.A.,Van Aalten, D.M.F.,Ferguson, M.A.J.; A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma Brucei.; Acs Chem.Biol., 8:1981-, 2013; PubMed: 23834437; DOI: 10.1021/CB400411X

実験手法

X-RAY DIFFRACTION (1.75 Å)