4BGQ
Crystal structure of the human CDKL5 kinase domain
Summary for 4BGQ
Entry DOI | 10.2210/pdb4bgq/pdb |
Descriptor | CYCLIN-DEPENDENT KINASE-LIKE 5, SODIUM ION, [4-({4-[(3-cyclopentyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile, ... (6 entities in total) |
Functional Keywords | transferase, phospho-mimetic, kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : O76039 |
Total number of polymer chains | 1 |
Total formula weight | 35856.35 |
Authors | Canning, P.,Krojer, T.,Goubin, S.,Mahajan, P.,Vollmar, M.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2013-03-28, release date: 2013-05-08, Last modification date: 2023-12-20) |
Primary citation | Canning, P.,Park, K.,Goncalves, J.,Li, C.,Howard, C.J.,Sharpe, T.D.,Holt, L.J.,Pelletier, L.,Bullock, A.N.,Leroux, M.R. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Cell Rep, 22:885-894, 2018 Cited by PubMed: 29420175DOI: 10.1016/j.celrep.2017.12.083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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