4BGQ
Crystal structure of the human CDKL5 kinase domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CYCLIN-DEPENDENT KINASE-LIKE 5 | polymer | 304 | 35231.7 | 1 | UniProt (O76039) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | SERINE/THREONINE-PROTEIN KINASE 9 |
| 2 | B (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 3 | C (A) | [4-({4-[(3-cyclopentyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile | non-polymer | 359.4 | 1 | Chemie (38R) | |||
| 4 | D, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | E, F (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 6 | H (A) | water | water | 18.0 | 152 | Chemie (HOH) |
Sequence modifications
A: 1 - 303 (UniProt: O76039)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Asp 169 | Thr 169 | engineered mutation |
| Glu 171 | Tyr 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35231.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 624.6 | |
| All* | Total formula weight | 35856.4 |
