4BGG

Crystal structure of the ACVR1 kinase in complex with LDN-213844

Summary for 4BGG

Entry DOI	10.2210/pdb4bgg/pdb
Descriptor	ACTIVIN RECEPTOR TYPE-1, 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine, CITRATE ANION, ... (5 entities in total)
Functional Keywords	transferase, inhibitor, bmp signalling
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Membrane; Single-pass type I membrane protein: Q04771
Total number of polymer chains	4
Total formula weight	141158.26
Authors	Sanvitale, C.,Canning, P.,Cooper, C.,Wang, Y.,Mohedas, A.H.,Choi, S.,Yu, P.B.,Cuny, G.D.,Nowak, R.,Coutandin, D.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2013-03-26, release date: 2013-04-10, Last modification date: 2023-12-20)
Primary citation	Mohedas, A.H.,Wang, Y.,Sanvitale, C.E.,Canning, P.,Choi, S.,Xing, X.,Bullock, A.N.,Cuny, G.D.,Yu, P.B. Structure-Activity Relationship of 3,5-Diaryl-2-Aminopyridine Alk2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants. J.Med.Chem., 57:7900-, 2014 Cited by PubMed: 25101911 DOI: 10.1021/JM501177W PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.56 Å)

Structure validation