4BGG
Crystal structure of the ACVR1 kinase in complex with LDN-213844
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ACTIVIN RECEPTOR TYPE-1 | polymer | 301 | 34537.6 | 4 | UniProt (Q04771) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | ACTIVIN RECEPTOR TYPE I, ACTR-I, ACTIVIN RECEPTOR-LIKE KINASE 2, ALK-2, SERINE/THREONINE-PROTEIN KINASE RECEPTOR R1, SKR1, TGF-B SUPERFAMILY RECEPTOR TYPE I, TSR-I |
| 2 | E, J, N, P (A, B, C, D) | 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine | non-polymer | 405.5 | 4 | Chemie (844) | |||
| 3 | F, G, H, K, L... (A, B, C) | CITRATE ANION | non-polymer | 189.1 | 7 | Chemie (FLC) | |||
| 4 | I (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | Q, R, S, T, U... (A, B, C, D) | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| Asp 207 | Gln 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138150.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3007.7 | |
| All* | Total formula weight | 141158.3 |
