4BFQ

Assembly of a triple pi-stack of ligands in the binding site of Aplysia californica acetylcholine binding protein (AChBP)

Summary for 4BFQ

• Entry DOI: 10.2210/pdb4bfq/pdb
• Descriptor: SOLUBLE ACETYLCHOLINE RECEPTOR, 4,6-dimethyl-N'-(3-pyridin-2-ylisoquinolin-1-yl)pyrimidine-2-carboximidamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: receptor, acetylcholine binding protein, nicotinic acetylcholine receptor, cys-loop receptor, nachr, ion channel, pi-stacking, triple ligand binding, drug design
• Biological source: APLYSIA CALIFORNICA (CALIFORNIA SEA HARE)
• Total number of polymer chains: 5
• Total formula weight: 128496.70

Authors

Stornaiuolo, M.,De Kloe, G.E.,Rucktooa, P.,Fish, A.,van Elk, R.,Edink, E.S.,Bertrand, D.,Smit, A.B.,de Esch, I.J.P.,Sixma, T.K. (deposition date: 2013-03-21, release date: 2013-05-22, Last modification date: 2023-12-20)

• Primary citation: Stornaiuolo, M.,De Kloe, G.E.,Rucktooa, P.,Fish, A.,van Elk, R.,Edink, E.S.,Bertrand, D.,Smit, A.B.,de Esch, I.J.P.,Sixma, T.K.; Assembly of a Pi-Pi Stack of Ligands in the Binding Site of an Acetylcholine Binding Protein; Nat.Commun., 4:1875-, 2013; PubMed: 23695669; DOI: 10.1038/NCOMMS2900

Experimental method

X-RAY DIFFRACTION (2.4 Å)