4AZE

Human DYRK1A in complex with Leucettine L41

Summary for 4AZE

• Entry DOI: 10.2210/pdb4aze/pdb
• Related: 2VX3 2WO6 4AZF
• Descriptor: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A, 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one (3 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus speckle: Q13627
• Total number of polymer chains: 6
• Total formula weight: 136142.56

Authors

Elkins, J.M.,Soundararajan, M.,Muniz, J.R.C.,Tahtouh, T.,Burgy, G.,Durieu, E.,Lozach, O.,Cochet, C.,Schmid, R.S.,Lo, D.C.,Delhommel, F.,Carreaux, F.,Bazureau, J.P.,Meijer, L.,Edwards, A.,Bountra, C.,Knapp, S. (deposition date: 2012-06-25, release date: 2012-09-05, Last modification date: 2023-12-20)

• Primary citation: Tahtouh, T.,Elkins, J.M.,Filippakopoulos, P.,Soundararajan, M.,Burgy, G.,Durieu, E.,Cochet, C.,Schmid, R.S.,Lo, D.C.,Delhommel, F.,Oberholzer, A.,Laurence, P.,Carreaux, F.,Bazureau, J.P.,Knapp, S.,Meijer, L.; Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.; J.Med.Chem., 55:9312-, 2012; PubMed: 22998443; DOI: 10.1021/JM301034U

Experimental method

X-RAY DIFFRACTION (3.15 Å)