4AYH

The X-ray structure of zinc bound ZinT

Summary for 4AYH

• Entry DOI: 10.2210/pdb4ayh/pdb
• Related: 4ARH 4AW8
• Descriptor: METAL-BINDING PROTEIN YODA, SULFATE ION, ZINC ION, ... (4 entities in total)
• Functional Keywords: metal binding protein, metal-binding protein, zinc transport
• Biological source: SALMONELLA ENTERICA
• Total number of polymer chains: 1
• Total formula weight: 21944.85

Authors

Alaleona, F.,Ilari, A.,Battistoni, A.,Petrarca, P.,Chiancone, E. (deposition date: 2012-06-21, release date: 2013-07-10, Last modification date: 2024-10-16)

Primary citation

Ilari, A.,Alaleona, F.,Tria, G.,Petrarca, P.,Battistoni, A.,Zamparelli, C.,Verzili, D.,Falconi, M.,Chiancone, E.
The Salmonella Enterica Zint Structure, Zinc Affinity and Interaction with the High-Affinity Uptake Protein Znua Provide Insight Into the Management of Periplasmic Zinc.
Biochim.Biophys.Acta, 1840:535-, 2014

PubMed Abstract: In Gram-negative bacteria the ZnuABC transporter ensures adequate zinc import in Zn(II)-poor environments, like those encountered by pathogens within the infected host. Recently, the metal-binding protein ZinT was suggested to operate as an accessory component of ZnuABC in periplasmic zinc recruitment. Since ZinT is known to form a ZinT-ZnuA complex in the presence of Zn(II) it was proposed to transfer Zn(II) to ZnuA. The present work was undertaken to test this claim.

PubMed: 24128931
DOI: 10.1016/J.BBAGEN.2013.10.010

Experimental method

X-RAY DIFFRACTION (2.52 Å)