4AW6

Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1)

Summary for 4AW6

Entry DOI	10.2210/pdb4aw6/pdb
Descriptor	CAAX PRENYL PROTEASE 1 HOMOLOG, ZINC ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE (3 entities in total)
Functional Keywords	hydrolase, m48 peptidase, integral membrane protein, prelamin a processing, ageing, progeria
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Endoplasmic reticulum membrane ; Multi-pass membrane protein : O75844
Total number of polymer chains	4
Total formula weight	226248.25
Authors	Pike, A.C.W.,Dong, Y.Y.,Quigley, A.,Dong, L.,Cooper, C.D.O.,Chaikuad, A.,Goubin, S.,Shrestha, L.,Li, Q.,Mukhopadhyay, S.,Yang, J.,Xia, X.,Shintre, C.A.,Barr, A.J.,Berridge, G.,Chalk, R.,Bray, J.E.,von Delft, F.,Bullock, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Burgess-Brown, N.,Carpenter, E.P. (deposition date: 2012-05-31, release date: 2012-07-25, Last modification date: 2018-01-24)
Primary citation	Quigley, A.,Dong, Y.Y.,Pike, A.C.W.,Dong, L.,Shrestha, L.,Berridge, G.,Stansfeld, P.J.,Sansom, M.S.P.,Edwards, A.M.,Bountra, C.,von Delft, F.,Bullock, A.N.,Burgess-Brown, N.A.,Carpenter, E.P. The Structural Basis of Zmpste24-Dependent Laminopathies. Science, 339:1604-, 2013 Cited by PubMed: 23539603 DOI: 10.1126/SCIENCE.1231513 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation