4AW6

Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1)

Summary for 4AW6

DescriptorCAAX PRENYL PROTEASE 1 HOMOLOG, ZINC ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE (3 entities in total)
Functional Keywordshydrolase, m48 peptidase, integral membrane protein, prelamin a processing, ageing, progeria
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationEndoplasmic reticulum membrane ; Multi-pass membrane protein  O75844
Total number of polymer chains4
Total molecular weight226248.25
Authors
Primary citation
Quigley, A.,Dong, Y.Y.,Pike, A.C.W.,Dong, L.,Shrestha, L.,Berridge, G.,Stansfeld, P.J.,Sansom, M.S.P.,Edwards, A.M.,Bountra, C.,von Delft, F.,Bullock, A.N.,Burgess-Brown, N.A.,Carpenter, E.P.
The Structural Basis of Zmpste24-Dependent Laminopathies.
Science, 339:1604-, 2013
PubMed: 23539603 (PDB entries with the same primary citation)
DOI: 10.1126/SCIENCE.1231513
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27720.2%2.4%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution