Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4AW6

Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003690	molecular_function	double-stranded DNA binding
A	0004175	molecular_function	endopeptidase activity
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005635	cellular_component	nuclear envelope
A	0005637	cellular_component	nuclear inner membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006508	biological_process	proteolysis
A	0006998	biological_process	nuclear envelope organization
A	0008233	molecular_function	peptidase activity
A	0008235	molecular_function	metalloexopeptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0031901	cellular_component	early endosome membrane
A	0031902	cellular_component	late endosome membrane
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
A	0050688	biological_process	regulation of defense response to virus
A	0051604	biological_process	protein maturation
A	0070062	cellular_component	extracellular exosome
A	0071586	biological_process	CAAX-box protein processing
B	0003690	molecular_function	double-stranded DNA binding
B	0004175	molecular_function	endopeptidase activity
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005635	cellular_component	nuclear envelope
B	0005637	cellular_component	nuclear inner membrane
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006508	biological_process	proteolysis
B	0006998	biological_process	nuclear envelope organization
B	0008233	molecular_function	peptidase activity
B	0008235	molecular_function	metalloexopeptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0032991	cellular_component	protein-containing complex
B	0046872	molecular_function	metal ion binding
B	0050688	biological_process	regulation of defense response to virus
B	0051604	biological_process	protein maturation
B	0070062	cellular_component	extracellular exosome
B	0071586	biological_process	CAAX-box protein processing
D	0003690	molecular_function	double-stranded DNA binding
D	0004175	molecular_function	endopeptidase activity
D	0004222	molecular_function	metalloendopeptidase activity
D	0005515	molecular_function	protein binding
D	0005635	cellular_component	nuclear envelope
D	0005637	cellular_component	nuclear inner membrane
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006508	biological_process	proteolysis
D	0006998	biological_process	nuclear envelope organization
D	0008233	molecular_function	peptidase activity
D	0008235	molecular_function	metalloexopeptidase activity
D	0008237	molecular_function	metallopeptidase activity
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0031901	cellular_component	early endosome membrane
D	0031902	cellular_component	late endosome membrane
D	0032991	cellular_component	protein-containing complex
D	0046872	molecular_function	metal ion binding
D	0050688	biological_process	regulation of defense response to virus
D	0051604	biological_process	protein maturation
D	0070062	cellular_component	extracellular exosome
D	0071586	biological_process	CAAX-box protein processing
E	0003690	molecular_function	double-stranded DNA binding
E	0004175	molecular_function	endopeptidase activity
E	0004222	molecular_function	metalloendopeptidase activity
E	0005515	molecular_function	protein binding
E	0005635	cellular_component	nuclear envelope
E	0005637	cellular_component	nuclear inner membrane
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006508	biological_process	proteolysis
E	0006998	biological_process	nuclear envelope organization
E	0008233	molecular_function	peptidase activity
E	0008235	molecular_function	metalloexopeptidase activity
E	0008237	molecular_function	metallopeptidase activity
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0031901	cellular_component	early endosome membrane
E	0031902	cellular_component	late endosome membrane
E	0032991	cellular_component	protein-containing complex
E	0046872	molecular_function	metal ion binding
E	0050688	biological_process	regulation of defense response to virus
E	0051604	biological_process	protein maturation
E	0070062	cellular_component	extracellular exosome
E	0071586	biological_process	CAAX-box protein processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1473

Chain	Residue
A	HIS335
A	GLU336
A	HIS339
A	GLU415

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PC1 A 1474

Chain	Residue
A	PHE271

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1473

Chain	Residue
B	HIS335
B	GLU336
B	HIS339
B	GLU415

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PC1 B 1474

Chain	Residue
B	PHE271

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1472

Chain	Residue
D	HIS335
D	GLU336
D	HIS339
D	GLU415

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PC1 D 1473

Chain	Residue
D	PHE271

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1472

Chain	Residue
E	HIS335
E	GLU336
E	HIS339
E	GLU415

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PC1 E 1473

Chain	Residue
E	PHE271

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	568
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	264
Details	Topological domain: {"description":"Nuclear","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	64
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"23539603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23539603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)