4ASK
CRYSTAL STRUCTURE OF JMJD3 WITH GSK-J1
Summary for 4ASK
Entry DOI | 10.2210/pdb4ask/pdb |
Related | 2XUE 2XXZ |
Descriptor | LYSINE-SPECIFIC DEMETHYLASE 6B, ZINC ION, 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, ... (5 entities in total) |
Functional Keywords | oxidoreductase, kdm6b, gsk-j1, inhibitor, lysine specific histone demethylase |
Biological source | HOMO SAPIENS |
Cellular location | Nucleus (Probable): O15054 |
Total number of polymer chains | 2 |
Total formula weight | 117128.15 |
Authors | Chung, C.,Mosley, J.,Liddle, J. (deposition date: 2012-05-01, release date: 2012-07-25, Last modification date: 2023-12-20) |
Primary citation | Kruidenier, L.,Chung, C.,Cheng, Z.,Liddle, J.,Che, K.,Joberty, G.,Bantscheff, M.,Bountra, C.,Bridges, A.,Diallo, H.,Eberhard, D.,Hutchinson, S.,Jones, E.,Katso, R.,Leveridge, M.,Mander, P.K.,Mosley, J.,Ramirez-Molina, C.,Rowland, P.,Schofield, C.J.,Sheppard, R.J.,Smith, J.E.,Swales, C.,Tanner, R.,Thomas, P.,Tumber, A.,Drewes, G.,Oppermann, U.,Patel, D.J.,Lee, K.,Wilson, D.M. A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response Nature, 488:404-, 2012 Cited by PubMed: 22842901DOI: 10.1038/NATURE11262 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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