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4ASE

CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH TIVOZANIB (AV-951)

Summary for 4ASE
Entry DOI10.2210/pdb4ase/pdb
Related1VR2 1Y6A 1Y6B 1YWN 2X1W 2X1X 2XIR 4AG8 4AGC 4AGD 4ASD
DescriptorVASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2, TIVOZANIB (3 entities in total)
Functional Keywordstransferase, angiogenesis, signaling protein, phosphorylation, receptor, inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight40713.25
Authors
McTigue, M.,Deng, Y.,Ryan, K.,Brooun, A.,Diehl, W.,Stewart, A. (deposition date: 2012-04-30, release date: 2012-09-26, Last modification date: 2023-12-20)
Primary citationMctigue, M.,Murray, B.W.,Chen, J.H.,Deng, Y.,Solowiej, J.,Kania, R.S.
Molecular Conformations, Interactions, and Properties Associated with Drug Efficiency and Clinical Performance Among Vegfr Tk Inhibitors.
Proc.Natl.Acad.Sci.USA, 109:18281-, 2012
Cited by
PubMed: 22988103
DOI: 10.1073/PNAS.1207759109
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.83 Å)
Structure validation

217705

건을2024-03-27부터공개중

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