4ARK
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MAP KINASE KINASE 1 (MEK1) IN COMPLEX WITH A SMALL MOLECULE INHIBITOR AND ADP
Summary for 4ARK
Entry DOI | 10.2210/pdb4ark/pdb |
Related | 1S9J 4AN2 4AN3 4AN9 4ANB |
Descriptor | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | transferase, kinase, inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750 |
Total number of polymer chains | 1 |
Total formula weight | 38860.34 |
Authors | Hartung, I.V.,Hitchcock, M.,Puehler, F.,Neuhaus, R.,Scholz, A.,Hammer, S.,Petersen, K.,Siemeister, G.,Brittain, D.,Hillig, R.C. (deposition date: 2012-04-24, release date: 2013-03-06, Last modification date: 2023-12-20) |
Primary citation | Hartung, I.V.,Hitchcock, M.,Puehler, F.,Neuhaus, R.,Scholz, A.,Hammer, S.,Petersen, K.,Siemeister, G.,Brittain, D.,Hillig, R.C. Optimization of Allosteric Mek Inhibitors - Part 1: Venturing Into Unexplored Sar Territories Bioorg.Med.Chem.Lett., 23:2384-, 2013 Cited by PubMed: 23474388DOI: 10.1016/J.BMCL.2013.02.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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